Symbol
Name
ID

Dock8
dedicator of cytokinesis 8
MGI:1921396

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgE level

Increased circulating IgG level

Decreased circulating total IgM

Subarachnoid hemorrhage

Anemia

Autoimmune hemolytic anemia

Coombs-positive hemolytic anemia

Iron deficiency anemia

Eosinophilia

Neutropenia

Neutropenia in presence of anti-neutropil antibodies

B lymphocytopenia

Decreased proportion of CD4-positive helper T cells

Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells

T lymphocytopenia

Reduced natural killer cell count

Decreased FOXP3-expressing T cell count

Thrombocytopenia

Autoimmune thrombocytopenia

Splenomegaly

Disease(s) Associated with DOCK8

hyper IgE recurrent infection syndrome 2

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

Mouse Phenotypes

abnormal cellular extravasation

decreased T cell proliferation

abnormal B cell differentiation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

decreased germinal center B cell number

decreased B-1 B cell number

decreased marginal zone B cell number

absent marginal zone B cells

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased activated T cell number

decreased spleen germinal center size

decreased IgG level

decreased IgM level

Availability

Mouse Genotype

Dock8^cpm/Dock8^cpm

Dock8^m1Anu/Dock8^m1Anu

Dock8^m1Btlr/Dock8^m1Btlr

Dock8^m2Anu/Dock8^m2Anu

Dock8^M2Btlr/Dock8^M2Btlr

Dock8^M3Btlr/Dock8^M3Btlr

Dock8^m4Btlr/Dock8^m4Btlr

Dock8^pri/Dock8^pri

Dock8^tm1Ysfk/Dock8^tm1Ysfk

Dock8^cpm/Dock8^pri

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23